CYP3A7 allele nomenclature

Allele	Protein__	Nucleotide changes		Effect	Enzyme activity		References________
		cDNA	Gene		In_vivo	In_vitro
CYP3A7*1A	CYP3A7.1 and CYP3A7.1L	None	None		Normal	Normal	Komoti et al, 1989 Rodriguez-Antona et al., 2005
CYP3A7*1B	CYP3A7.1	-314C>T	-314C>T				Kuehl et al, 2001
CYP3A7*1C	CYP3A7.1	-291G>T; -284T>A; -282T>C; -281A>T; -270T>G; -262T>A; -232A>C	-291G>T; -284T>A; -282T>C; -281A>T; -270T>G; -262T>A; -232A>C			Incr.	Kuehl et al, 2001 Sim et al., 2005
CYP3A7*1D	CYP3A7.1	-91G>A	-91G>A				Kuehl et al, 2001
CYP3A7*1E	CYP3A7.1	-49G>A	-49G>A				Kuehl et al, 2001
CYP3A7*2	CYP3A7.2	1226C>G	26041C>G	T409R		Incr.	Rodríguez-Antona et al., 2005
CYP3A7*3	CYP3A7.3	141_142insT	4011_4012insT	48Frameshift			Shin et al., manuscript in preparation

Changes made since the last update (13-Nov-2007) are marked in red.

Links to the NCBI dbSNP homepage are available for functional SNPs when present in NCBI's database.

Nucleotide variations in bold are the major SNPs/alterations responsible for the phenotype of the corresponding allele.

OMIM GeneCards

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Home Page Inclusion criteria
CYP1A1 CYP1A2 CYP1B1 CYP2A6 CYP2A13 CYP2B6 CYP2C8 CYP2C9 CYP2C19 CYP2D6 CYP2E1 CYP2F1 CYP2J2
CYP2R1 CYP2S1 CYP2W1 CYP3A4 CYP3A5 CYP3A7 CYP3A43 CYP4A11 CYP4A22 CYP4B1 CYP4F2 CYP5A1 CYP8A1 CYP19A1 CYP21A2 CYP26A1 POR

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