CYP4A22 allele nomenclature

Allele	Protein	Nucleotide changes		Effect	Enzyme activity		References
		cDNA	Gene		In_vivo	In_vitro
CYP4A22*1	CYP4A22.1	None	None		Normal	Normal
CYP4A22*2	CYP4A22.2	31C>T; 454A>T; 691T>C; 969C>T	31C>T; 4694A>T; 6332T>C; 7136C>T	R11C; N152Y; C231R			Hiratsuka et al., 2006
CYP4A22*3A		31C>T; 454A>T; 691T>C; 900delG	31C>T: 4694A>T; 6332T>C; 7067delG	R11C; N152Y; C231R; 300Frameshift			Hiratsuka et al., 2006
CYP4A22*3B		31C>T; 454A>T; 900delG	31C>T; 4694A>T; 7067delG	R11C; N152Y; 300Frameshift			Hiratsuka et al., 2006
CYP4A22*3C		454A>T; 691T>C; 900delG	4694A>T; 6332T>C; 7067delG	N152Y; C231R; 300Frameshift			Hiratsuka et al., 2006
CYP4A22*3D		454A>T; 691T>C; 900delG; 1102C>T	4694A>T; 6332T>C; 7067delG; 7365C>T	N152Y; C231R; 300Frameshift			Hiratsuka et al., 2006
CYP4A22*3E		454A>T; 691T>C; 900delG; 1283T>C	4694A>T; 6332T>C; 7067delG; 8441T>C	N152Y, C231R, 300Frameshift			Hiratsuka et al., 2006
CYP4A22*4	CYP4A22.4	388G>A; 454A>T; 691T>C; 969C>T	4628G>A; 4694A>T; 6332T>C; 7136C>T	G130S; N152Y; C231R			Hiratsuka et al., 2006
CYP4A22*5	CYP4A22.5	454A>T; 691T>C; 969C>T	4694A>T; 6332T>C; 7136C>T	N152Y; C231R			Hiratsuka et al., 2006
CYP4A22*6	CYP4A22.6	454A>T; 691T>C; 1283T>C	4694A>T;  6332T>C; 8441T>C	N152Y; C231R; L428P			Hiratsuka et al., 2006
CYP4A22*7	CYP4A22.7	454A>T; 691T>C; 969C>T; 1525C>T	4694A>T; 6332T>C; 7136C>T; 11277C>T	N152Y; C231R; L509F			Hiratsuka et al., 2006
CYP4A22*8	CYP4A22.8	376C>T; 454A>T; 691T>C; 827A>C	4124C>T; 4694A>T; 6332T>C; 6908A>C	R126W; N152Y; C231R; K276T			Hiratsuka et al., 2006
CYP4A22*9	CYP4A22.9	376C>T; 454A>T; 691T>C; 1283T>C	4124C>T; 4694A>T; 6332T>C; 8441T>C	R126W; N152Y; C231R; L428P			Hiratsuka et al., 2006
CYP4A22*10	CYP4A22.10	388G>A; 454A>T; 553G>T; 691T>C; 1283T>C; 1525C>T	4628G>A; 4694A>T; 5826G>T; 6332T>C; 8441T>C; 11277C>T	G130S; N152Y; V185F; C231R; L428P; L509F			Hiratsuka et al., 2006
CYP4A22*11	CYP4A22.11	376C>T; 454A>T; 553G>T; 691T>C; 827A>C; 1525C>T	4124C>T; 4694A>T; 5826G>T; 6332T>C; 6908A>C; 11277C>T	R126W; N152Y; V185F; C231R; K276T; L509F			Hiratsuka et al., 2006
CYP4A22*12A	CYP4A22.12	376C>T; 388G>A; 454A>T; 553G>T; 691T>C; 1283T>C	4124C>T; 4628G>A; 4694A>T; 5826G>T; 6332T>C; 8441T>C	R126W; G130S; N152Y; V185F; C231R; L428P			Hiratsuka et al., 2006
CYP4A22*12B	CYP4A22.12	376C>T; 388G>A; 454A>T; 553G>T; 691T>C; 1170A>C; 1283T>C	4124C>T; 4628G>A; 4694A>T; 5826G>T; 6332T>C; 7433A>C; 8441T>C	R126W; G130S; N152Y; V185F; C231R; L428P			Hiratsuka et al., 2006
CYP4A22*13A	CYP4A22.13	376C>T; 388G>A; 454A>T; 553G>T; 691T>C; 1283T>C; 1525C>T	4124C>T; 4628G>A; 4694A>T; 5826G>T; 6332T>C; 8441T>C; 11277C>T	R126W; G130S; N152Y; V185F; C231R; L428P; L509F			Hiratsuka et al., 2006
CYP4A22*13B	CYP4A22.13	376C>T; 388G>A; 454A>T; 553G>T; 691T>C; 1170A>C; 1283T>C; 1525C>T	4124C>T; 4628G>A; 4694A>T; 5826G>T; 6332T>C; 7433A>C; 8441T>C; 11277C>T	R126W; G130S; N152Y; V185F; C231R; L428P; L509F			Hiratsuka et al., 2006
CYP4A22*14	CYP4A22.14	376C>T; 388G>A; 454A>T; 553G>T; 691T>C; 827A>C; 1525C>T	4124C>T; 4628G>A; 4694A>T; 5826G>T; 6332T>C; 6908A>C; 11277C>T	R126W; G130S; N152Y; V185F; C231R; K276T; L509F			Hiratsuka et al., 2006
CYP4A22*15	CYP4A22.15	376C>T; 388G>A; 454A>T; 553G>T; 691T>C; 827A>C; 1283T>C; 1525C>T	4124C>T; 4628G>A; 4694A>T; 5826G>T; 6332T>C; 6908A>C; 8441T>C; 11277C>T	R126W; G130S; N152Y; V185F; C231R; K276T; L428P; L509F			Hiratsuka et al., 2006

Changes made since the last update (13-Nov-2007) are marked in red.

Links to the NCBI dbSNP homepage are available for functional SNPs when present in NCBI's database.

Nucleotide variations in bold are the major SNPs/alterations responsible for the phenotype of the corresponding allele.

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