CYP3A7 allele nomenclature

Allele	Protein__	Nucleotide changes		Effect	Enzyme activity		References________
		cDNA	Gene		In_vivo	In_vitro
CYP3A7*1A	CYP3A7.1 and CYP3A7.1L	None	None		Normal	Normal	Komoriet al, 1989 Rodriguez-Antona et al., 2005
CYP3A7*1B	CYP3A7.1	-314C>T	-314C>T				Kuehl et al, 2001
CYP3A7*1C	CYP3A7.1	-291G>T; -284T>A; -282T>C; -281A>T; -270T>G; -262T>A; -232A>C	-291G>T; -284T>A; -282T>C; -281A>T; -270T>G; -262T>A; -232A>C			Incr.	Kuehl et al, 2001 Sim et al., 2005
CYP3A7*1D	CYP3A7.1	-91G>A	-91G>A				Kuehl et al, 2001
CYP3A7*1E	CYP3A7.1	-49G>A	-49G>A				Kuehl et al, 2001
CYP3A7*2	CYP3A7.2	1226C>G	26041C>G	T409R		Incr.	Rodríguez-Antona et al., 2005
CYP3A7*3	CYP3A7.3	141_142insT	4011_4012insT	48 Frameshift			Lee et al., 2010

Changes made since the last update (13-Nov-2007) are marked in red.

Links to the NCBI dbSNP homepage are available for functional SNPs when present in NCBI's database.

Nucleotide variations in bold are the major SNPs/alterations responsible for the phenotype of the corresponding allele.

OMIM GeneCards