CYP2J2 allele nomenclature

Allele	Protein	Nucleotide changes		Effect	Enzyme activity		References
		cDNA	Gene		In_vivo	In_vitro
CYP2J2*1	CYP2J2.1	None	None		Normal	Normal
CYP2J2*2	CYP2J2.2	427A>G	14488A>G	T143A		Reduced AA and LA metabolism	King et al., 2002
CYP2J2*3	CYP2J2.3	472C>T	14533C>T	R158C		Reduced AA and LA metabolism	King et al., 2002
CYP2J2*4	CYP2J2.4	575T>A	15029T>A	I192N		Reduced AA metabolism	King et al., 2002
CYP2J2*5	CYP2J2.5	1024G>A	21709G>A	D342N		Normal metabolism of AA and LA	King et al., 2002
CYP2J2*6	CYP2J2.6	1210A>T	25662A>T	N404Y		Reduced AA and LA metabolism	King et al., 2002
CYP2J2*7	CYP2J2.7		-76G>T		Decr.	Reduced transcription due to loss of Sp1 binding site	King et al., 2002 Spiecker et al., 2004
CYP2J2*8	CYP2J2.8	934G>A	18892G>A	G312R			Shin et al., 2005
CYP2J2*9	CYP2J2.9	1052C>T	21737C>T	P351L			Shin et al., 2005
CYP2J2*10	CYP2J2.10	344C>T	10780C>T	P115L			Gaedigk et al., 2006

AA, arachidonic acid; LA, linoleic acid

Changes made since the last update (27-Mar-2007) are marked in red.

Links to the NCBI dbSNP homepage are available for functional SNPs when present in NCBI's database.

Nucleotide variations in bold are the major SNPs/alterations responsible for the phenotype of the corresponding allele.

OMIM GeneCards