CYP2B6 allele nomenclature

Allele	Protein	Nucleotide changes		Effect	Enzyme activity		References
		cDNA	Gene		In_vivo	In_vitro
CYP2B6*1A	CYP2B6.1				Normal	Normal
CYP2B6*1B	CYP2B6.1		-2320T>C				Lamba et al., 2003
CYP2B6*1C	CYP2B6.1		-2320T>C; 14593C>G; 15582C>T				Lamba et al., 2003
CYP2B6*1D	CYP2B6.1		-1778A>G; -1186C>G; 12917A>T				Lamba et al., 2003
CYP2B6*1E	CYP2B6.1		-1578C>T; -757C>T				Lamba et al., 2003
CYP2B6*1F	CYP2B6.1		-1224A>G				Lamba et al., 2003
CYP2B6*1G	CYP2B6.1		-750T>C				Lamba et al., 2003
CYP2B6*1H	CYP2B6.1		-2320T>C; -750T>C				Hesse et al., 2004
CYP2B6*1J	CYP2B6.1		-2320T>C; -1778A>G; -1186C>G; -750T>C				Hesse et al., 2004
CYP2B6*1K	CYP2B6.1		-1972C>T; -1578C>T; -750T>C				Hesse et al., 2004
CYP2B6*1L	CYP2B6.1		-1578C>T; -750T>C				Hesse et al., 2004
CYP2B6*1M	CYP2B6.1		-1578C>T				Hesse et al., 2004
CYP2B6*1N	CYP2B6.1		-1456T>C; -750T>C				Hesse et al., 2004
CYP2B6*2A	CYP2B6.2	64C>T	64C>T	R22C			Lang et al., 2001
CYP2B6*2B	CYP2B6.2	64C>T; 216G>C	64C>T; 12740G>C	R22C			Lamba et al., 2003
CYP2B6*3	CYP2B6.3	777C>A	18045C>A	S259R			Lang et al., 2001
CYP2B6*4A	CYP2B6.4	785A>G	18053A>G	K262R	Incr.		Lang et al., 2001 Kirchheiner et al., 2003
CYP2B6*4B	CYP2B6.4	785A>G	-2320T>C; -1778A>G; -1186C>G; -750T>C; 18053A>G	K262R			Hesse et al., 2004
CYP2B6*4C	CYP2B6.4	785A>G	18053A>G; 12917A>T	K262R			Jacob et al., 2004
CYP2B6*4D	CYP2B6.4	785A>G	-1456T>C; -750T>C; 18053A>G	K262R			Zukunft et al., 2005
CYP2B6*5A	CYP2B6.5	1459C>T	25505C>T	R487C			Lang et al., 2001
CYP2B6*5B	CYP2B6.5	1459C>T	-2320T>C; -750T>C; 25505C>T	R487C			Hesse et al., 2004
CYP2B6*5C	CYP2B6.5	1459C>T	-591A>G; 25505C>T	R487C			Zukunft et al., 2005
CYP2B6*6A	CYP2B6.6	516G>T; 785A>G	15631G>T; 18053A>G	Q172H; K262R	Decr.	Decr. expr.	Lang et al., 2001 Tsuchiya et al., 2004 Hofmann et al., 2008
CYP2B6*6B	CYP2B6.6	516G>T; 785A>G	-1456T>C; -750T>C; 15631G>T; 18053A>G	Q172H; K262R			Hesse et al., 2004
CYP2B6*6C	CYP2B6.6	516G>T; 785A>G	-750T>C; 15631G>T; 18053A>G	Q172H; K262R			Zukunft et al., 2005
CYP2B6*7A	CYP2B6.7	516G>T; 785A>G 1459C>T	15631G>T; 18053A>G; 25505C>T	Q172H; K262R; R487C			Lang et al., 2001
CYP2B6*7B	CYP2B6.7	516G>T; 785A>G 1459C>T	-1456 T>C; -750T>C; 15631G>T; 18053A>G; 25505C>T	Q172H; K262R; R487C			Hesse et al., 2004
CYP2B6*8	CYP2B6.8	415A>G	13072A>G	K139E		Decr. expr.	Lamba et al., 2003 Lang et al., 2004
CYP2B6*9	CYP2B6.9	516G>T	-1456T>C; 15631G>T; 21563C>T	Q172H			Lamba et al., 2003
CYP2B6*10	CYP2B6.10	62A>T; 64C>T; 216G>C	62A>T; 64C>T; 12740G>C	Q21L; R22C			Lang et al., 2004
CYP2B6*11A	CYP2B6.11	136A>G	136A>G	M46V		Decr. expr.	Lang et al., 2004
CYP2B6*11B	CYP2B6.11	136A>G	136A>G; 18273G>A	M46V		Decr. expr.	Lang et al., 2004
CYP2B6*12 Tentative allele	CYP2B6.12	296G>A	12820G>A; 18273G>A	G99E		Decr. expr.	Lang et al., 2004
CYP2B6*13A	CYP2B6.13	415A>G; 516G>T; 785A>G	13072A>G; 15631G>T; 18053A>G; 18273G>A; 21563C>T	K139E; Q172H; K262R		Decr.?	Lang et al., 2004
CYP2B6*13B	CYP2B6.13	415A>G; 516G>T; 785A>G	13072A>G; 15582C>T; 15631G>T; 18053A>G; 18273G>A; 21563C>T	K139E; Q172H; K262R		Decr.?	Lang et al., 2004
CYP2B6*14 Tentative allele	CYP2B6.14	419G>A	13076G>A; 18273G>A	R140Q		Decr. act.	Lang et al., 2004
CYP2B6*15A	CYP2B6.15	1172T>A	15582C>T; 21388T>A	I391N		Decr. expr.	Lang et al., 2004
CYP2B6*15B	CYP2B6.15	1172T>A	15582C>T; 18273G>A; 21388T>A	I391N		Decr. expr.	Lang et al., 2004
CYP2B6*16	CYP2B6.16	785A>G; 983T>C	18053A>G, 21011T>C	K262R; I328T	Decr.	Decr. expr.	Wang et al., 2006
CYP2B6*17A	CYP2B6.17	76A>T; 83A>G; 85C>A; 86G>C; 933C>T	76A>T; 83A>G; 85C>A; 86G>C; 18273G>A; 18799C>T	T26S; D28G; R29T			Klein et al., 2005
CYP2B6*17B	CYP2B6.17	76A>T; 83A>G; 85C>A; 86G>C	76A>T; 83A>G; 85C>A; 86G>C; 18273G>A	T26S; D28G; R29T			Klein et al., 2005
CYP2B6*18	CYP2B6.18	983T>C	17897C>T; 18273G>A; 18627G>A; 21011T>C	I328T		Decr. expr.	Klein et al., 2005
CYP2B6*19	CYP2B6.19	516G>T; 785A>G; 1006C>T	15631G>T; 18053A>G; 18273G>A; 21034C>T; 21563C>T	Q172H; K262R; R336C		Decr. expr.	Klein et al., 2005
CYP2B6*20	CYP2B6.20	503C>T; 516G>T; 785A>G;	15618C>T; 15631G>T; 18053A>G; 18273G>A	T168I; Q172H; K262R		Decr. expr.	Klein et al., 2005
CYP2B6*21	CYP2B6.21	1282C>A	18273G>A; 21498C>A	P428T		Decr. expr.	Klein et al., 2005
CYP2B6*22	CYP2B6.1		-1848C>A; -801G>T; -750T>C, -82T>C	Incr. transcr.		Incr. expr.	Zukunft et al., 2005
CYP2B6*23	CYP2B6.23	1375A>G	25421A>G	M459V			Hiratsuka et al., 2004
CYP2B6*24	CYP2B6.24	1427G>A	25473G>A	G476D			Hiratsuka et al., 2004
CYP2B6*25	CYP2B6.25	1454A>T	25500A>T	Q485L			Hiratsuka et al., 2004
CYP2B6*26	CYP2B6.26	499C>G; 516G>T; 785A>G	15614C>G; 15631G>T; 18053A>G	P167A; Q172H; K262R	Decr.		Gatanaga et al., 2007
CYP2B6*27	CYP2B6.27	593T>C	15708T>C; 18273G>A	M198T		Decr	Rotger et al., 2007a
CYP2B6*28		917C>G; 1132C>T	-1456T>C; -750T>C; 15837C>T; 18273G>A; 18627G>A; 18783C>G; 18912G>C; 21160C>T	T306S; R378X		None	Rotger et al., 2007a
CYP2B6*29	CYP2B6.29	CYP2B7/CYP2B6 hybrid (crossover in intron 4) 6A>G; 42A>C; 66C>T; 76A>T; 83A>G; 85C>A; 86G>C; 123A>G; 141T>C; 264T>G; 273G>C; 305C>T; 309G>C; 310G>A; 312C>G; 319T>G; 323T>A; 326G>A; 336T>C; 337G>A; 340A>C; 393T>C; 444G>C; 468G>A; 486G>A; 493A>G; 516G>T; 547G>A; 561A>C; 593T>C; 608A>G; 614C>G; 618T>C; 620C>T; 634G>A; 638T>C; 640G>A	CYP2B7/CYP2B6 hybrid (crossover in intron 4) 6A>G; 42A>C; 66C>T; 76A>T; 83A>G; 85C>A; 86G>C; 123A>G; 141T>C; 12788T>G; 12797G>C; 12829C>T; 12833G>C; 12834G>A; 12836C>G; 12843T>G; 12847T>A; 12850G>A; 12993T>C; 12994G>A; 12997A>C; 13050T>C; 13101G>C; 13125G>A; 15601G>A; 15608A>G; 15631G>T; 15662G>A; 15676A>C; 15708T>C; 15723A>G; 15729C>G; 15733T>C; 15735C>T; 15749G>A; 15753T>C; 15755G>A	T26S; D28G; R29T; K91N; A102V; M103I; V104M; F107V; F108Y; R109Q; V113M; I114L; E148D; M165V; Q172H; V183I; M198T; Y203C; T205S; S207L; V212I; F213S; G214S			Rotger et al., 2007b
CYP2B6*30	CYP2B6.30	CYP2B6/CYP2B7 hybrid (crossover in intron 4)					Martis et al., 2012
CYP2B6*31	CYP2B6.31	937C>A	Rs 193922917	L313I			Röhrich et al., 2016
CYP2B6*32	CYP2B6.32	1219G>A	Rs 193922918	A407T			Röhrich et al., 2016
CYP2B6*33	CYP2B6.33	1459C>A	25505C>A	R487S			Radloff et al., 2013
CYP2B6*34	CYP2B6.34	516G>T; 785A>G; 1459C>A	-82T>C; 15631G>T; 18053A>G; 25505C>A	Q172H; K262R; R487S			Radloff et al., 2013
CYP2B6*35	CYP2B6.35	201G>A; 264T>G; 329G>T; 341T>C; 444G>T; 465G>A; 593T>C; 835G>C	-82T>C; 12725G>A; 12788T>G; 12853G>T; 12998T>C; 13101G>T; 13122G>A; 15708T>C; 18701G>C	G110V; I114T; E148D; M198T; A279P			Radloff et al., 2013
CYP2B6*36	CYP2B6.6	516G>T; 785A>G	-82T>C; 15631G>T; 18053A>G	Q172H; K262R			Radloff et al., 2013
CYP2B6*37	CYP2B6.37	516G>T; 548T>G; 785A>G	15631G>T; 15663T>G; 18053A>G	Q172H; V183G; K262R			Radloff et al., 2013
CYP2B6*38	CYP2B6.38	186T>A; 516G>T; 785A>G	12710T>A; 15631G>T; 18053A>G; 18273G>A; 21563C>T	Y62X; Q172H; K262R			Anagnostopoulos et al., 2013
Additional SNPs, where the haplotype has not yet been determined
			18000C>T				Lang et al., 2001
			17808G>A; 18273A>G; 18604G>A				Saito et al., 2003
			297C>T; 365T>A; 12940delAG; 13198T>A; 15290T>G; 15414G>A; 15415C>A; 15482C>T; 15577C>G; 15794G>A; 17522A>T; 17670G>A; 17755G>C; 18166G>C; 18674C>T; 25548G>A; 25660C>A; 25866T>A; 25867A>G; 25883A>G; 26147C>G; 26594G>T; 26777G>A; 26921A>C; 26922G>A				Solus et al., 2004
			18026G>A	R253H			Radloff et al., 2013
			15752T>C	F213L			Radloff et al., 2013
			There exists a haplotype with both the characteristic CYP2B6*6 and CYP2B6*14 SNPs, although allele designations of such a haplotype awaits additional gene sequencing.	A yet not fully characterized haplotype of Q172H, K262R, and R140Q exists			Guo-Avrutin et al., personal communication

Changes made since the update (28-Nov-2013) are marked in red.

Allele frequencies: Solus et al., 2004

Links to the NCBI dbSNP homepage are available for functional SNPs when present in NCBI's database.

Nucleotide variations in bold are the major SNPs/alterations responsible for the phenotype of the corresponding allele.

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